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Polyoxidonium injection (Polioksidoniy, Azoximeri bromidum, Azoximer bromide) - has immunomodulatory effects. The preparation increases the resistance of the body against bacterial, fungal and viral infections. The basis of the mechanism of immunomodulatory effects Polyoxidonium is to increase the ability of white blood cells phagocytose microbes and stimulate initially at low rates the production of cytokines that activate the immune system, increases antibody to infectious agents.
Polyoxidonium activates phagocytes of peripheral blood and tissue macrophages, which contributes to more rapid elimination of the pathogen from the body in the presence of the infection. Furthermore, Polyoxidonium activate lymphoid cells in the regional lymph nodes, namely the B-cells that produce secretory IgA.
With sublingual application Polyoxidonium activates lymphoid cells in the nasal cavity, the Eustachian tubes, oropharynx, bronchi. Furthermore, Polyoxidonium saliva activates bactericidal properties.
When administered orally Polyoxidonium also activate lymphoid cells located in the intestinal lymph nodes.
The consequence of this is to increase the stability of the respiratory, gastrointestinal and upper respiratory tract to infectious agents.
Along with immunomodulatory effects, has expressed Polyoxidonium detoxification and antioxidant activity, has the ability to rid the body of toxins, heavy metals, inhibits lipid peroxidation. These properties are determined by the structure and nature of the high-molecular Polyoxidonium
Application Polyoxidonium on the background of secondary immunodeficient states to improve the efficiency and reduce the duration of treatment, significantly reduce the use of antibiotics, bronchodilators, corticosteroids, lengthen remission.
The drug is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, it does not have allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.
Polyoxidonium is used in adults and adolescents over 12 years for the treatment and prevention of infectious and inflammatory diseases (viral, bacterial and fungal etiologies) are not amenable to standard therapy. Polyoxidonium used both in the acute stage, and in remission:
in the treatment of:
Intramuscularly or intravenously (infusion): a drug prescribed to adults in doses of 6-12 mg 1 time a day every day, every other day, or 1-2 times per week depending on the diagnosis and the severity of the disease.
For intramuscular or contents of the vial bottle were dissolved in 0.9 mL of 1.5-2% chloride, water for injection or sodium chloride. For intravenous (drip) administering the drug dissolved in 2 ml of 0.9% sodium chloride solution gemodez-H
Reopoliglyukina or 5% dextrose solution and then aseptically transferred to a vial containing said solution a volume of 200-400 ml.
The prepared solution for parenteral administration must not be stored.
Intranasal: 6 mg dose was dissolved in 1 ml (20 drops) of distilled water, 0.9% sodium chloride solution or boiled water at room temperature.
Recommended treatment scheme adults
In acute inflammatory diseases: 6 mg daily for 3 days, then every other day a total rate of 5-10 injections.
In chronic inflammatory diseases: 6 mg 5 injections every other day, then two times a week course of at least 10 injections.
In tuberculosis: 6-12 mg 2 times a week course of 10-20 injections.
In patients with acute and chronic urogenital diseases: 6 mg every other day course of 10 injections in combination with chemotherapy.
In chronic recurrent herpes: 6 mg every other day course of 10 injections in combination with antiviral drugs, interferon and / or inducers of synthesis of interferon.
For the treatment of complicated forms of allergic diseases: 6 mg, the course of 5 injections: the first two injections every day, then every other day. In acute allergic and toxic-allergic conditions administered intravenously at 6-12 mg in combination with anti-allergic drugs.
In rheumatoid arthritis: 6 mg 5 injections every other day, then two times a week course of at least 10 injections.
In cancer patients:
- Up to and during chemotherapy to reduce the immunosuppressive, hepato- and nephrotoxic action of chemotherapeutic agents on 6-12 mg a day rate of not less than 10 injections; further injection frequency is determined by the doctor depending on tolerability and duration of chemotherapy and radiation therapy;
- Immunosuppressive effect for preventing tumor correction of immunodeficiency after chemotherapy and radiotherapy after surgical removal of the tumor is shown Polioksidoniy® prolonged use of the preparation (from 2-3 months to 1 year) at 6-12 mg 1-2 times a week.
In patients with acute renal failure appoint not more than 2 times per week.
Intranasally administered 6 mg per day for the treatment of acute and chronic infections of upper respiratory tract, to enhance the regenerative processes of the mucous membranes, to prevent complications and recurrence of diseases, for the prevention of influenza and acute respiratory disease. 3 drops in each nostril 2-3 hours (three times a day) during days 5-10.
DOSAGE AND ADMINISTRATION FOR CHILDREN
Methods of Use Polioksidoniy preparation: parenterally, intranasally, sublingually. Methods of application are selected depending on the physician diagnosis, severity of the disease, age and body weight of the patient.
Parenteral drug administered to children 6 months at a dose of 3 mg (intramuscularly or intravenously 0.1-015 mg / kg) daily, every other day or 2 times a week course of 5-10 injections (doses indicated in the table calculation).
For intramuscular administration, the preparation is dissolved in 1 ml of water for injection or 0.9% sodium chloride solution.
For intravenous drip preparation is dissolved in 1.5-2 ml of sterile 0.9% sodium chloride, reopoliglyukina, gemodez-H or 5% dextrose solution, transferred to a sterile vial containing said solution a volume of 150-250 ml.
Intranasally and sublingually daily at a daily dose of 0.15 mg / kg for 5-10 days. The drug is administered for 1-3 drops in one nostril or under the tongue 2-3 hours.
To prepare the solution for intranasal and sublingual dose of 3 mg dissolved in 1 ml (20 drops), the dose of 6 mg - 2 ml of distilled water, 0.9% sodium chloride solution or boiled water at room temperature. One drop of the prepared solution (50 l) contained 0.15 mg Polioksidoniy® which are assigned to 1 kg body weight.
The solution for sublingual and intranasal application store in the refrigerator no more than 7 days. Before use with pipette solution should be warmed to room temperature (20-25 ° C).
Recommended schemes of treatment of children
Intranasally administered 1-3 drops into one nostril 2-3 hours (2-4 times daily). For intranasal and sublingual administration the daily dose for children calculation is shown in Table.
5 kg - 5 drops 0.25 ml
10 kg - 0.5 ml 10 drops
15 kg - 0.75 ml 15 drops
20 kg - 1.00 ml 20 drops
Sublingual: all readings - day in a daily dose of 0.15 mg / kg for 10 days, for the treatment of intestinal dysbiosis during 10-20 days. Drip 1-3 drops under the tongue 2-3 hours.
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